Sex differences in the association between energy‐adjusted dietary inflammatory index and cognitive function in older adults
E-DII exhibits sex-specific associations with multiple cognitive domains in older adults. Higher ln(E-DII) is linked to poorer verbal fluency (AFT), processing speed (DSST), and increased low cognition risk (AFT, DSST, and DRT) in older males, but not in older females. Gamma-glutamyl transferase mediates the association between ln(E-DII) and DSST performance specifically in older males. Findings support the development of personalized, sex-specific dietary strategies to preserve cognitive health in aging populations.
Authors
- Peili Cen (ORCID: https://orcid.org/0000-0003-1497-2209)
- Chentao Jin (ORCID: https://orcid.org/0000-0002-4238-1564)
- Rui Zhou (ORCID: https://orcid.org/0000-0002-4491-4811)
- Yuanjie Chen (ORCID: https://orcid.org/0000-0003-4011-4005)
- Xiaohui Zhang (ORCID: https://orcid.org/0000-0002-4575-0775)
- Ke Liu (ORCID: https://orcid.org/0000-0002-4683-9325)
- Yuhan Chen (ORCID: https://orcid.org/0000-0002-2950-2675)
- Jing Wang (ORCID: https://orcid.org/0000-0003-4896-0142)
- Yuan Sun (ORCID: https://orcid.org/0009-0002-9894-460X)
- Liangliang Dong
- Hong Zhang (ORCID: https://orcid.org/0000-0002-5408-4292)
- Daoyan Hu
- Yan Zhong (ORCID: https://orcid.org/0009-0001-2288-8034)
- Mei Tian
Institutions
- Ministry of Education (NZ)
- Fudan University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/alz.70908
- Primary Topic
- Nutritional Studies and Diet
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities
- Natural Science Foundation of Zhejiang Province