A Comparative Analysis in the Treatment of Full-Thickness Wounds: Negative-Pressure Wound Therapy (NPWT) Combined With High-Purity Type I Collagen-Based Skin Substitute Versus NPWT Alone
The combination of NPWT with HPTC skin substitute (Helicoll<sup>®</sup>) significantly accelerates wound healing and faster closure, improves histopathological parameters, and has better scar outcomes in full-thickness wounds compared to NPWT alone. These findings support incorporating HPTC-based skin substitutes in complex wound care protocols, and this combination therapy represents a promising advancement in wound management.
Authors
- Naveen Narayan (ORCID: https://orcid.org/0000-0001-7125-5842)
- Vikram Ramamurthy
- Shivannaiah Chethan (ORCID: https://orcid.org/0000-0001-7845-2152)
- Suhas Gowda
- Divakara S Raghupathi
Institutions
- Institute of Medical Sciences (IN)
Publication Details
- Journal
- Cureus
- Published
- 2025-11-16
- DOI
- https://doi.org/10.7759/cureus.96977
- Citations
- 2
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.05