Characterization of diffusivity and mechanical properties of polyethylene glycol hydrogel conformal coatings over time for application in beta cell replacement therapy for type 1 diabetes
This report demonstrated a novel measurement technique capable of assessing the mechanical and transport properties of individually coated samples, giving a more precise characterization of inherent variabilities within a sample population. Moreover, the approach is adaptable to other therapeutic cell clusters and organoids, supporting broader applications in cell transplantation therapies and offering a robust method for batch release validation in clinical applications.
Authors
- Noa H. deHaseth (ORCID: https://orcid.org/0000-0001-6923-1497)
- Aaron A. Stock (ORCID: https://orcid.org/0000-0001-6940-7333)
- Giuseppe Orlando (ORCID: https://orcid.org/0000-0002-6460-7974)
- Noël Ziebarth (ORCID: https://orcid.org/0000-0001-5959-4454)
- Alice A. Tomei (ORCID: https://orcid.org/0000-0002-5059-6303)
- Grisell C. Gonzalez (ORCID: https://orcid.org/0000-0001-6743-1620)
- Ana L. Claure
Institutions
- University of Miami (US)
Publication Details
- Journal
- Cellular and Molecular Bioengineering
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1007/s12195-025-00878-7
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Diabetes Research Institute Foundation
- University of Miami
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases