Comparing Palliative Approaches for GOO in Locally Advanced Pancreatic Cancer: A Systematic Review and Meta‐Analysis
Gastric outlet obstruction (GOO) in locally advanced pancreatic cancer (LAPC) can be managed with endoscopic duodenal stenting (EDS), gastrojejunostomy (GJ), or EUS-guided gastroenterostomy (EUS-GE). In our meta-analysis of LAPC patients, EDS enabled quicker recovery and chemotherapy but had higher re-intervention rates, while GJ offered greater durability. Our systematic review showed EUS-GE had high success and low re-intervention in malignant GOO, though LAPC-specific data were lacking. Further comparative studies are needed to guide individualized treatment.
Authors
- Toms Augustin (ORCID: https://orcid.org/0000-0001-6063-9859)
- Asad Gul Rao (ORCID: https://orcid.org/0009-0004-4197-2786)
- Tyler Stevens (ORCID: https://orcid.org/0000-0002-8027-8496)
- Chase J. Wehrle (ORCID: https://orcid.org/0000-0002-9275-4744)
- Abdul Rafeh Awan (ORCID: https://orcid.org/0000-0002-6411-8759)
- Abby Gross (ORCID: https://orcid.org/0000-0002-5497-5634)
- Samer A. Naffouje (ORCID: https://orcid.org/0000-0003-4973-9597)
- David E. Joyce (ORCID: https://orcid.org/0009-0002-5054-3794)
- Muhammad Nadeem (ORCID: https://orcid.org/0000-0001-5941-4695)
- Hassan Siddiki (ORCID: https://orcid.org/0000-0002-7830-8780)
- Kathryn A. Stackhouse (ORCID: https://orcid.org/0000-0003-3756-7150)
- Richard Matthew Walsh (ORCID: https://orcid.org/0000-0002-8937-2702)
- Robert L. Simon
- Rob Naples
- Syed Mohiuddin
- Beren Berber
- Antonio Giuseppucci
Institutions
- Cleveland Clinic (US)
- Nishtar Medical College and Hospital (PK)
- Dow University of Health Sciences (PK)
Publication Details
- Journal
- Journal of Surgical Oncology
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1002/jso.70131
- Primary Topic
- Esophageal and GI Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00