SPINK1-driven cellular heterogeneity and interaction networks in intrahepatic cholangiocarcinoma revealed by integrated multi-omics analysis
Our findings uncover a novel SPINK1-CCL20-LAMs axis that orchestrates immune recruitment and metabolic reprogramming in ICC. SPINK1 facilitates tumor growth by establishing a glutamine-rich microenvironment via LAMs. These insights highlight SPINK1 as a potential therapeutic target and prognostic biomarker in ICC.
Authors
- Mingyu Wan (ORCID: https://orcid.org/0000-0002-2592-0917)
- Yunlu Jia (ORCID: https://orcid.org/0000-0003-2213-7561)
- Dayong Zheng (ORCID: https://orcid.org/0000-0003-1885-3485)
- Gautam Sethi (ORCID: https://orcid.org/0000-0002-8677-8475)
- Chanqi Ye (ORCID: https://orcid.org/0000-0003-1321-3059)
- Jinzhang Chen (ORCID: https://orcid.org/0000-0003-4881-4663)
- Jian Ruan (ORCID: https://orcid.org/0000-0003-1354-4720)
- Wenguang Fu
- Xiaoxiang Rong (ORCID: https://orcid.org/0000-0002-5058-2067)
- Qiong Li (ORCID: https://orcid.org/0000-0001-9044-0074)
- Jiayun Guan
- Rui Zhou (ORCID: https://orcid.org/0000-0002-0737-3040)
- Ruyin Chen (ORCID: https://orcid.org/0000-0003-4698-233X)
Institutions
- National University of Singapore (SG)
- Affiliated Hospital of Southwest Medical University (CN)
- The First People's Hospital of Shunde (CN)
- Nanfang Hospital (CN)
- National University Cancer Institute, Singapore (SG)
- First Affiliated Hospital Zhejiang University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.jare.2025.11.011
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00