Frontal Cortex Stimulation Modulates Attentional Circuits and Increases Anxiety-Potentiated Startle in Anxious Depression
tDCS enhanced executive function and task engagement, as evidenced by improved accuracy, reaction times, and frontal activation. However, it failed to reduce threat sensitivity as hypothesized. Contextual interventions engaging target circuits during stimulation may optimize tDCS efficacy as an adjunctive treatment for anxious depression. Future studies should explore synergistic therapeutic approaches.
Authors
- Tate Poplin
- Robin L. Aupperle (ORCID: https://orcid.org/0000-0003-2173-6140)
- Rayus Kuplicki (ORCID: https://orcid.org/0000-0003-2954-6421)
- Maria Ironside (ORCID: https://orcid.org/0000-0003-2781-1711)
- Ebony A. Walker
- Nicholas L. Balderston (ORCID: https://orcid.org/0000-0002-8565-1544)
- Martin P. Paulus (ORCID: https://orcid.org/0000-0002-0825-3606)
- Kara N. Goldman (ORCID: https://orcid.org/0000-0002-5455-627X)
- Cheldyn Ramsey
Institutions
- Oklahoma State University (US)
- Laureate Institute for Brain Research (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Biological Psychiatry Cognitive Neuroscience and Neuroimaging
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.bpsc.2025.10.020
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00