Olink proteomics profiling platform reveals myocardial metabolism-associated protein biomarkers in heart failure with preserved ejection fraction (HFpEF)
In this study, we identified DPP4, KIT, and SELL as HFpEF-specific biomarkers. These three biomarkers, individually and combined in a predictive model, demonstrated excellent diagnostic performance, providing clinicians with a novel tool for rapid HFpEF diagnosis. Furthermore, our findings offer new insights into the complex pathophysiological mechanisms underlying HFpEF.
Authors
- Yimei Huang (ORCID: https://orcid.org/0000-0002-2011-4844)
- Shensheng Nian
- Yuchi Hu
- Hongshou Li (ORCID: https://orcid.org/0000-0001-8588-122X)
- Chuanxin Li
- Xinyun Chen (ORCID: https://orcid.org/0000-0002-2055-310X)
- Liping Liu (ORCID: https://orcid.org/0000-0003-2943-055X)
- Ling Zhao (ORCID: https://orcid.org/0000-0001-6822-8632)
- Xi Zhai
- Songyuan Dai (ORCID: https://orcid.org/0009-0007-2442-5854)
- Lulu Zhao
Institutions
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- Clinica Chimica Acta
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1016/j.cca.2025.120717
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00