Single-cell multi-omics and spatial transcriptomics reveal the transcriptional regulatory landscape of clear cell renal cell carcinoma
This study elucidates cellular heterogeneity, the epigenetic regulatory landscape, and the key genes driving ccRCC progression. The integration of multi-omics data offers novel insights into precise diagnostic strategies and therapeutic interventions, highlighting the pivotal role of genes such as <i>YBX3</i>.
Authors
- Xiaofu Qiu (ORCID: https://orcid.org/0000-0002-9246-6531)
- Zemin Wan (ORCID: https://orcid.org/0000-0001-5832-4436)
- Jianchun Duan (ORCID: https://orcid.org/0000-0003-3300-1707)
- Chuling Wu
- Bangqi Wang (ORCID: https://orcid.org/0000-0002-2142-1969)
- Zhi Lv (ORCID: https://orcid.org/0009-0009-6072-8160)
- Yifeng He (ORCID: https://orcid.org/0000-0003-2345-0736)
- Zongtai Zheng (ORCID: https://orcid.org/0000-0001-7962-5166)
- Peifeng Ke (ORCID: https://orcid.org/0000-0003-2106-6327)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
Publication Details
- Journal
- Translational Andrology and Urology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tau-2025-328
- Citations
- 2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 1.61