Ursolic acid sensitizes bladder cancer to gemcitabine chemotherapy by concurrently targeting PI3K/AKT and JNK pathways
UA sensitizes BCa to GEM chemotherapy by promoting apoptosis, mediated through PI3K/AKT inactivation and JNK activation. These findings highlight UA as a promising adjunct to GEM therapy, warranting further clinical exploration.
Authors
- Pan Juncheng (ORCID: https://orcid.org/0000-0003-4626-3511)
- Xiaolong Huang (ORCID: https://orcid.org/0000-0003-4535-071X)
- Hang Tong (ORCID: https://orcid.org/0000-0002-6583-3017)
- Junlong Zhu (ORCID: https://orcid.org/0000-0002-9389-8256)
- Wen Peng (ORCID: https://orcid.org/0000-0002-7939-676X)
- Weiyang He (ORCID: https://orcid.org/0000-0002-7445-8781)
- Yan Sun (ORCID: https://orcid.org/0009-0007-1247-2979)
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- First People's Hospital of Chongqing (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Translational Andrology and Urology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tau-2025-383
- Citations
- 2
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.61