Final validation of the hierarchical framework for outcomes in axial spondyloarthritis: longitudinal determinants of health-related quality of life
A validated longitudinal framework has been established for interpreting HRQoL: even correcting for contextual factors, disease activity consistently impacts HRQoL-primarily through functional impairment, but also directly. While HRQoL is an overarching outcome in axSpA, targeting low disease activity is crucial to optimise HRQoL.
Authors
- Sofia Ramiro
- Augusta Ortolan (ORCID: https://orcid.org/0000-0002-3131-0939)
- Laure Gossec (ORCID: https://orcid.org/0000-0002-4528-310X)
- Désirée M F M van der Heijde (ORCID: https://orcid.org/0000-0002-5781-158X)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Inserm (FR)
- Leiden University Medical Center (NL)
- Agostino Gemelli University Polyclinic (IT)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institut Pierre Louis d‘Épidémiologie et de Santé Publique (FR)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2025-11-17
- DOI
- https://doi.org/10.1016/j.ard.2025.10.016
- Citations
- 1
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.67
Funders
- Eli Lilly and Company
- Pfizer
- Biogen
- Celltrion Healthcare
- Celltrion
- Institut National de la Santé et de la Recherche Médicale