Icariside II attenuates renal fibrosis through mTOR signaling modulation: an integrated approach combining network pharmacology, molecular dynamics, and in vitro validation

ICA-II demonstrates anti-fibrotic effects through a multi-target, multi-pathway regulatory network. Its beneficial role in RF may involve direct inhibition of mTOR activity, thereby attenuating excessive extracellular matrix (ECM) accumulation. These findings provide a theoretical and experimental basis for ICA-II as a promising candidate for the treatment of RF.

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Publication Details

Journal
Translational Andrology and Urology
Published
2025-10-01
DOI
https://doi.org/10.21037/tau-2025-395
Primary Topic
Medicinal Plant Pharmacodynamics Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Icariside II attenuates renal fibrosis through mTOR signaling modulation: an integrated approach combining network pharmacology, molecular dynamics, and in vitro validation

Zhongcheng Xin, Changli Wu, Pingyun Ding, Yuhong Feng et al.
Translational Andrology and Urology
Medicinal Plant Pharmacodynamics Research
article

Icariside II attenuates renal fibrosis through mTOR signaling modulation: an integrated approach combining network pharmacology, molecular dynamics, and in vitro validation

Zhongcheng Xin, Changli Wu, Pingyun Ding, Yuhong Feng, Jiancheng Pan, Wenjie Tian, Ge Gao, Yongjiao Yang
article en

Abstract

ICA-II demonstrates anti-fibrotic effects through a multi-target, multi-pathway regulatory network. Its beneficial role in RF may involve direct inhibition of mTOR activity, thereby attenuating excessive extracellular matrix (ECM) accumulation. These findings provide a theoretical and experimental basis for ICA-II as a promising candidate for the treatment of RF.

Translational Andrology and UrologyVol. 14(10)
Tianjin Central Hospital of Gynecology Obstetrics (CN), Second Hospital of Tianjin Medical University (CN), Second Affiliated Hospital of Jilin University (CN), Tianjin Medical University (CN)
Openalex Percentile: Top 56%
Medicinal Plant Pharmacodynamics Research
DOIOpen Access PDFOpenAlex
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Icariside II attenuates renal fibrosis through mTOR signaling modulation: an integrated approach combining network pharmacology, molecular dynamics, and in vitro validation — Zhongcheng Xin, Changli Wu, et al. · Translational Andrology and Urology (2025) | TGRS Research Map | TGRS