Actionable Genomic Alterations in Large Cell Neuroendocrine Carcinoma: A European Case Series of Patients Treated With a Small Molecule Inhibitor
In our series, patients with LCNEC harboring AGAs who are treated with SMIs achieved a response in 50% of cases, including durable responses. However, only half of the patients with LCNEC are screened for AGAs. These findings highlight the need for standardized testing for AGAs in LCNEC.
Authors
- Ernst‐Jan M. Speel (ORCID: https://orcid.org/0000-0002-3016-2989)
- Jan H. von der Thüsen (ORCID: https://orcid.org/0000-0001-9699-4860)
- Mathew Carter
- Lisa M. Hillen (ORCID: https://orcid.org/0000-0002-8808-4952)
- Anne‐Marie C. Dingemans (ORCID: https://orcid.org/0000-0001-6105-182X)
- Petros Christopoulos (ORCID: https://orcid.org/0000-0002-7966-8980)
- Colin R. Lindsay (ORCID: https://orcid.org/0000-0001-8167-5461)
- Mario Occhipinti (ORCID: https://orcid.org/0000-0002-7169-5343)
- Y. Lage
- Jules L. Derks (ORCID: https://orcid.org/0000-0002-0442-1879)
- Judith Herder
- Frans Schutgens (ORCID: https://orcid.org/0009-0007-5642-7440)
- Wieneke A. Buikhuisen (ORCID: https://orcid.org/0000-0002-0799-7187)
- Pilar Garrido (ORCID: https://orcid.org/0000-0002-5899-6125)
- Marta Brambilla (ORCID: https://orcid.org/0000-0003-1148-7056)
- Liudmila L. Kodach (ORCID: https://orcid.org/0000-0003-2487-3204)
- Daniele Lorenzini (ORCID: https://orcid.org/0000-0002-1425-3354)
- Miep A. van der Drift
- Frank W J Heijboer (ORCID: https://orcid.org/0009-0009-4108-3969)
- Wouter K. de Jong
- Rieneke Britstra
- Ronald Damhuis (ORCID: https://orcid.org/0000-0001-7248-7047)
- Amparo Benito (ORCID: https://orcid.org/0000-0002-1312-4892)
- Albrecht Stenzinger
Institutions
- Radboud University Nijmegen (NL)
- Heidelberg University (DE)
- Maastricht University Medical Centre (NL)
- Erasmus MC (NL)
- University Hospital Heidelberg (DE)
- Radboud University Medical Center (NL)
- University of Manchester (GB)
- The Netherlands Cancer Institute (NL)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- Cancer Research UK Manchester Institute (GB)
- The Christie NHS Foundation Trust (GB)
- Netherlands Comprehensive Cancer Organisation (NL)
- Erasmus MC Cancer Institute (NL)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Meander Medisch Centrum (NL)
- Maastro Clinic (NL)
- Hospital Universitario Ramón y Cajal (ES)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1200/po-25-00293
- Citations
- 1
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 1.35