Multiple System Atrophy Without Dysautonomia
The MDS-MSA criteria expand the diagnostic scope by identifying a motor-only subgroup with a distinct and potentially slower disease course. These findings underscore the importance of including motor-only patients in natural history and interventional studies. Limitations include retrospective data collection and potential variability in symptom documentation.
Authors
- Anthony E. Lang (ORCID: https://orcid.org/0000-0003-1229-3667)
- Ida Jensen (ORCID: https://orcid.org/0009-0006-0270-0029)
- Laura Molina‐Porcel (ORCID: https://orcid.org/0000-0003-4068-8578)
- John Cornelis Van Swieten (ORCID: https://orcid.org/0000-0001-6278-6844)
- Elise G.P. Dopper
- Alexander Bernhardt (ORCID: https://orcid.org/0000-0002-2572-5062)
- Gábor G. Kovács
- Annemieke J.M. Rozemüller (ORCID: https://orcid.org/0000-0003-2528-4428)
- Christer Nilsson (ORCID: https://orcid.org/0000-0003-1186-8115)
- Sarah Bebermeier (ORCID: https://orcid.org/0000-0001-7921-4543)
- Joseph Seemiller (ORCID: https://orcid.org/0000-0001-7742-8759)
- Franziska Hopfner (ORCID: https://orcid.org/0000-0001-6524-0281)
- Claire Troakes (ORCID: https://orcid.org/0000-0002-1790-7376)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- S Berger (ORCID: https://orcid.org/0000-0001-7548-5442)
- Alexander Pantelyat (ORCID: https://orcid.org/0000-0002-6427-7485)
- Johanne Heine
- Nathaniel Bendahan (ORCID: https://orcid.org/0000-0003-2167-5667)
- Sabrina Katzdobler (ORCID: https://orcid.org/0000-0002-3512-5984)
- Edward B. Lee (ORCID: https://orcid.org/0000-0002-4589-1180)
- Elisabet Englund (ORCID: https://orcid.org/0000-0002-2708-2443)
- Günter U. Höglinger (ORCID: https://orcid.org/0000-0001-7587-6187)
- Jochen Herms (ORCID: https://orcid.org/0000-0002-6201-1042)
- Jesse Cohen (ORCID: https://orcid.org/0000-0003-2554-5181)
- Mojtaba Nemati
- Viktoria Ruf
- Yaroslau Compta (ORCID: https://orcid.org/0000-0001-6443-0104)
- David J. Irwin (ORCID: https://orcid.org/0000-0002-5599-5098)
- Albert Vamanu
- S Downes
Institutions
- Leibniz University Hannover (DE)
- Pennsylvania State University (US)
- University Health Network (CA)
- Johns Hopkins University (US)
- King's College London (GB)
- Lund University (SE)
- Toronto Western Hospital (CA)
- Johns Hopkins Medicine (US)
- German Center for Neurodegenerative Diseases (DE)
- Erasmus MC (NL)
- LMU Klinikum (DE)
- University of Florida (US)
- Medizinische Hochschule Hannover (DE)
- Jacksonville University (US)
- Amsterdam Neuroscience (NL)
- Occupational Cancer Research Centre (CA)
- Institute for Neurodegenerative Disorders (US)
- Munich Cluster for Systems Neurology (DE)
- Hospital Clínic de Barcelona (ES)
- L3S Research Center (DE)
- Institute on Aging (US)
- Ontario Brain Institute (CA)
- University of Pennsylvania (US)
- Ludwig-Maximilians-Universität München (DE)
- Penn State Milton S. Hershey Medical Center (US)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Neurology
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1212/wnl.0000000000214316
- Citations
- 1
- Primary Topic
- Hereditary Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Biogen
- Teva Pharmaceutical Industries
- University of Pennsylvania
- Fondation Brain Canada
- Demensförbundet
- Edmond J. Safra Philanthropic Foundation
- Ludwig-Maximilians-Universität München
- Parkinson Canada
- National Institutes of Health
- Parkinsonfonden
- Bayer Vital
- Canadian Institutes of Health Research