Increased expression of Toll-like receptors and associated alarmins in temporal arteries of patients with giant cell arteritis
TLRs are overexpressed at the site of vascular inflammation in C-GCA and at a lower level in EC-GCA and PMR with negative TAB. Moreover, HMGB-1, SAA, and fibrinogen may serve as disease biomarkers of patients with C-GCA.
Authors
- Santos Castañeda (ORCID: https://orcid.org/0000-0002-7748-853X)
- Miguel Ángel González-Gay (ORCID: https://orcid.org/0000-0002-7924-7406)
- Marisa Pardines (ORCID: https://orcid.org/0009-0004-7379-9375)
- Georg Wietzorrek (ORCID: https://orcid.org/0000-0003-2372-8267)
- Michael Schirmer (ORCID: https://orcid.org/0000-0001-9208-7809)
- José A. Jiménez‐Heffernan (ORCID: https://orcid.org/0000-0002-2113-2972)
- Sandra Santos‐Sierra (ORCID: https://orcid.org/0000-0002-4691-3003)
- Miren de las Fuentes Monreal (ORCID: https://orcid.org/0000-0003-4037-3082)
- S. Seidlberger
Institutions
- Universidad de Cantabria (ES)
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
- University of the Witwatersrand (ZA)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Hospital Universitario de La Princesa (ES)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s10020-025-01390-4
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Austrian Science Fund
- Ministerio de Economía y Competitividad
- Foundation for Research in Rheumatology
- Instituto de Salud Carlos III