Pregnancy Outcomes Following Paternal Methotrexate Exposure: A Systematic Review and Meta‐Analysis
Paternal MTX exposure was not associated with increased risks of congenital malformations, stillbirth, or preterm birth, nor with a consistent or recurrent pattern of anomalies. These findings provide reassurance regarding fetal safety following paternal MTX exposure.
Authors
- Tijen Kaya Temiz (ORCID: https://orcid.org/0000-0002-0069-6576)
- Nusret Uysal (ORCID: https://orcid.org/0000-0002-0009-3951)
- Yusuf Cem Kaplan (ORCID: https://orcid.org/0000-0003-0369-7934)
- Hüseyin Yılmaz (ORCID: https://orcid.org/0000-0001-6401-0767)
- Barış Karadaş (ORCID: https://orcid.org/0000-0003-0917-2186)
- Mesut Gungor (ORCID: https://orcid.org/0009-0000-5681-1599)
- Ahmet Özyürek
Institutions
- Izmir Kâtip Çelebi University (TR)
- Marmara University (TR)
- Pharmaceuticals and Medical Devices Agency (JP)
Publication Details
- Journal
- Birth Defects Research
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/bdr2.2542
- Primary Topic
- Pregnancy and Medication Impact
- Type
- article
- Field-Weighted Citation Impact
- 0.00