Topical vancomycin for surgical site infection prophylaxis in craniotomies and noninstrumented spinal procedures: a randomized controlled trial
Topical vancomycin did not result in any significant reduction in SSI compared to the current standard of care. The authors believe that further research is needed to determine the role of topical vancomycin in neurosurgery, and that its use should not be established as the standard of care in the absence of clear evidence of its superiority over current prophylactic treatments.
Authors
- Jan Claassen (ORCID: https://orcid.org/0000-0002-5893-8531)
- Alison R Clarke (ORCID: https://orcid.org/0000-0002-0205-6644)
- Adithya Kannan (ORCID: https://orcid.org/0000-0001-7359-184X)
- E. Sander Connolly (ORCID: https://orcid.org/0000-0002-6877-3371)
- William Pennington-FitzGerald
- Brandon R. Christophe
- Damian E Teasley (ORCID: https://orcid.org/0000-0002-8139-8115)
- Peter D. Angevine (ORCID: https://orcid.org/0000-0003-1468-8611)
- Emilia Bagiella (ORCID: https://orcid.org/0000-0002-3582-6502)
- Jared Knopman (ORCID: https://orcid.org/0000-0001-5871-5517)
Institutions
- Cornell University (US)
- Columbia University Irving Medical Center (US)
- University of Pittsburgh Medical Center (US)
- Neurological Surgery (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of neurosurgery
- Published
- 2025-11-15
- DOI
- https://doi.org/10.3171/2025.6.jns23694
- Primary Topic
- Surgical site infection prevention
- Type
- article
- Field-Weighted Citation Impact
- 0.00