Seizures and Epilepsy in Patients With Untreated Cerebral Cavernous Malformations
The risk of a first-ever epileptic seizure from CCM is low. Four of 5 patients who experience a first unprovoked epileptic seizure develop a recurrent seizure within 10 years, justifying diagnosis of CRE after a first unprovoked epileptic seizure due to CCM. Most of the patients with CRE achieve 2-year/5-year seizure freedom within 10 years. These long-term findings can inform patients and guide clinical practice.
Authors
- W. Peter Vandertop (ORCID: https://orcid.org/0000-0001-5417-0265)
- Jonathan M. Coutinho (ORCID: https://orcid.org/0000-0002-8284-982X)
- Phil White (ORCID: https://orcid.org/0000-0001-6007-6013)
- Rustam Al‐Shahi Salman (ORCID: https://orcid.org/0000-0002-2108-9222)
- Dagmar Verbaan (ORCID: https://orcid.org/0000-0002-9212-5470)
- Abel Clemens Adriaan Sandmann (ORCID: https://orcid.org/0009-0008-9744-8544)
Institutions
- Translational Research Institute (AU)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
- University of Edinburgh (GB)
Publication Details
- Journal
- Neurology
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1212/wnl.0000000000214387
- Citations
- 1
- Primary Topic
- Vascular Malformations Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Stichting de Drie Lichten
- Koninklijke Nederlandse Akademie van Wetenschappen