Mixed Molecular Subtypes Coexist in Estrogen Receptor Heterogeneous Primary Breast Cancers
This study demonstrates mixed Lum-A and Lum-B molecular subtypes within ER-intermediate primary breast cancers and reveals that ER- tumor cell populations have molecular features of endocrine resistance but chemotherapy sensitivity. These findings may explain the worse clinical outcomes of patients with ER-heterogeneous breast cancers and suggest benefit from combined endocrine and chemotherapy strategies.
Authors
- Steffi Oesterreich (ORCID: https://orcid.org/0000-0002-2537-6923)
- Haiying Zhan (ORCID: https://orcid.org/0009-0009-2233-9551)
- Julia Foldi (ORCID: https://orcid.org/0000-0002-7504-867X)
- Sneha Burela (ORCID: https://orcid.org/0000-0003-0287-0336)
- Lajos Pusztai (ORCID: https://orcid.org/0000-0001-9632-6686)
- David L. Rimm (ORCID: https://orcid.org/0000-0001-5820-4397)
- Adrian V. Lee (ORCID: https://orcid.org/0000-0001-9917-514X)
- Fangyuan Chen (ORCID: https://orcid.org/0000-0002-9891-4753)
- Giampaolo Bianchini (ORCID: https://orcid.org/0000-0002-6790-6267)
- Matteo Dugo (ORCID: https://orcid.org/0000-0001-9786-2763)
- Charles T. Robbins (ORCID: https://orcid.org/0000-0002-3130-7107)
- Jiawei Dai (ORCID: https://orcid.org/0000-0003-3806-5160)
- Matthew Liu (ORCID: https://orcid.org/0000-0002-2229-5124)
- Kaitlyn Xiong (ORCID: https://orcid.org/0000-0001-9764-6745)
- Philipp L Karn
Institutions
- University of Pittsburgh (US)
- Universität Ulm (DE)
- Yale University (US)
- Magee-Womens Research Institute (US)
- UPMC Hillman Cancer Center (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1200/po-25-00529
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00