Decoding the ceRNA regulatory landscape: a comprehensive transcriptomic analysis of ncRNA-driven bladder fibrosis following spinal cord injury
This first comprehensive transcriptomic atlas of SCI-induced NB uncovers dynamic ncRNA-mRNA networks driving fibrosis through TGF-β and inflammatory pathways. The identified dysregulated ncRNAs and their target genes provide novel biomarkers for early NB diagnosis and potential therapeutic entry points. Our findings establish a foundation for developing ncRNA-targeted strategies to mitigate bladder remodeling post-SCI, addressing a critical unmet need in neuro-urology.
Authors
- Tongwen Ou (ORCID: https://orcid.org/0000-0001-8055-9418)
- Hao Yan (ORCID: https://orcid.org/0000-0003-0578-7212)
- Jimeng Ruan (ORCID: https://orcid.org/0000-0003-3948-3129)
- Zhenhua Shang (ORCID: https://orcid.org/0000-0001-8570-7096)
- Bo Cui (ORCID: https://orcid.org/0000-0001-7128-7705)
- Xin Cui (ORCID: https://orcid.org/0000-0001-7560-6910)
Institutions
- Capital Medical University (CN)
Publication Details
- Journal
- Translational Andrology and Urology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tau-2025-376
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00