Sex-divergent association of testosterone with suicidal risk in late-life depression

This study demonstrates a critical sex-dependent dichotomy: higher sex-normalized testosterone protects elderly depressed males against suicidality but elevates risk in females, warranting longitudinal validation.

Authors

Qian Zhao (ORCID: https://orcid.org/0000-0002-2943-0229)
Bingbing Fu
Han Wang (ORCID: https://orcid.org/0009-0008-4147-8912)
Juan Huang (ORCID: https://orcid.org/0000-0003-4292-4642)
Nan Lyu

Institutions

Beijing Anding Hospital (CN)

Publication Details

Journal: Journal of Affective Disorders
Published: 2025-11-11
DOI: https://doi.org/10.1016/j.jad.2025.120664
Primary Topic: Hormonal and reproductive studies
Type: article
Field-Weighted Citation Impact: 0.00

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article

Sex-divergent association of testosterone with suicidal risk in late-life depression

Qian Zhao, Bingbing Fu, Han Wang, Juan Huang et al.

Nov 11, 2025

Journal of Affective Disorders

Hormonal and reproductive studies

article

Sex-divergent association of testosterone with suicidal risk in late-life depression

Qian Zhao, Bingbing Fu, Han Wang, Juan Huang, Nan Lyu

November 11, 2025article en

Abstract

Journal of Affective DisordersVol. 394(Pt B)

Beijing Anding Hospital (CN)

Openalex Percentile: Top 54%

Hormonal and reproductive studies

DOI Open Access PDF OpenAlex

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Sex-divergent association of testosterone with suicidal risk in late-life depression — Qian Zhao, Bingbing Fu, et al. · Journal of Affective Disorders (2025) | TGRS Research Map | TGRS