Synthesis, Characterization and Biological Activity Studies of New Metal Ion Complexes With Schiff Base Derived from (Z)-3-Hydrazineylidene-1-Phenylpyrazolidine and Evaluating Them as Antioxidants

The research includes the preparation of several complexes of the transition elements and zinc where M(II) = Co, Ni, Cu, and Zn, containing the 3d shell, with ligand (LH)was synthesized by treating the (Z)-3-hydrazineylidene-1-phenylpyrazolidine and Salicylaldehyde. Ligand (LH) was identified using FT-IR spectra,1H-13C-NMR, UV-Vis spectroscopy, elemental microanalysis CHN and mass spectrometry. The complexes were studied and identified with elemental microanalysis CHN, FT-IR spectroscopy, UV-Vis spectroscopy, conductivity measurement, and magnetic sensitivity. The result showed that, these complexes were classified as homogeneous tridentate complexes with the formula [M(LH) (H2O)2Cl] or [M(LH)2]. xH2O. The physical measurements indicated that the prepared complexes are non-electrolyte and showed that the ligand is tridentate when coordinated with metal ions through the nitrogen of azomethine (-C=N-), oxygen atom of (O-H) and the nitrogen(N-H) of Pyrazolidinone octahedral geometry for all complexes with good yield. This study emphasized the importance of using a metal complexation method to stabilize ligands and increase their bioactivity. The biological screening of the complexes demonstrates that the Schiff base metal complexes exhibit remarkable efficacy in combating microorganisms, by utilizing Pseudomonas, E. coli, strepto and staph as bacterial strains using doxycycline, tetracycline, clindamycin, rifampin, clarithromycin, levofloxacin, amikacin, ceftriaxone, vancomycin, ampicillin as reference to determine Pharmacological resistance to negative and positive bacteria. Hence, their results were good in inhibition. Then, the potential of these prepared compounds as antioxidants was determined by inhibiting free radicals using DPPH as a free radical.