Emergence of novel sublineages of Mycobacterium tuberculosis in Pakistan
Collectively, these observations highlight Lineage 3's ability to acquire first-line drug resistance continued transmission. Its predominance in the current study highlights the urgent need for lineage-specific diagnostics, enhanced drug susceptibility testing and tailored therapeutic regimens. The detection of diverse Mtb sublineages, including L3.1.2.1 and various sublineages of L4 (e.g., 4.1.1.1, 4.1.2.1, 4.3.4.2, and 4.6.2.2), signifies advancement in understanding the genetic landscape of TB in the region.
Authors
- Chendi Zhu (ORCID: https://orcid.org/0000-0003-0956-4278)
- Irfan Ahmad (ORCID: https://orcid.org/0000-0002-9500-4623)
- Dalal Sulaiman Alshaya (ORCID: https://orcid.org/0000-0002-0682-8189)
- Taane Gregory Clark (ORCID: https://orcid.org/0000-0001-8985-9265)
- Muhammad Tahir Khan (ORCID: https://orcid.org/0000-0001-8657-8150)
- Arwa Omar Al Khatib (ORCID: https://orcid.org/0000-0001-9445-3315)
- Ahmed Ali Al-Qahtani (ORCID: https://orcid.org/0000-0003-4584-5739)
Institutions
- Al-Ahliyya Amman University (JO)
- Princess Nourah bint Abdulrahman University (SA)
- Alfaisal University (SA)
- Capital Medical University (CN)
- London School of Hygiene & Tropical Medicine (GB)
- Beijing Chest Hospital (CN)
- State Key Laboratory of Respiratory Disease (CN)
- King Khalid University (SA)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- International Journal of Medical Microbiology
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1016/j.ijmm.2025.151684
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00