Sex-Specific Associations of Irritability With Subcortical Brain Volumes
Sex-specific subcortical correlates may explain sex-specific differences in the behavioral presentation of irritability. In models of irritability, the subcortex governs initiation of angry responses, which are dampened by prefrontal cortices. The altered volumes in reward-related regions in boys and threat-related regions in girls reported herein may be markers of early risk for irritability and/or possible targets for brain-informed interventions. Girls may benefit from irritability treatments targeting threat-based pathways, and boys may benefit from treatments targeting reward-based pathways.
Authors
- Juan Sanchez‐Peña
- Hajer Nakua
- Gaurav H. Patel (ORCID: https://orcid.org/0000-0003-0028-2098)
- Jacob W. Cohen (ORCID: https://orcid.org/0000-0002-6846-0201)
- David Pagliaccio (ORCID: https://orcid.org/0000-0002-1214-1965)
- David Semanek
- Mariah L. DeSerisy (ORCID: https://orcid.org/0000-0002-3936-9708)
- Amy E. Margolis (ORCID: https://orcid.org/0000-0002-3334-6783)
- Huiyu Yang
Institutions
- Columbia University Irving Medical Center (US)
- New York Psychoanalytic Society and Institute (US)
- Child Mind Institute (US)
- New York State Psychiatric Institute
- The Ohio State University (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100653
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00