Neddylation: from regulatory mechanisms to clinical implications in cancer
This review constructs a multi-dimensional pathogenic network of neddylation at a systematic level, providing a comprehensive elaboration of its molecular basis in governing key cancer characteristics through modulating protein functions and cellular activities. Simultaneously, we focus on targeted therapeutic strategies against this pathway, analyzing the clinical potential and future directions of novel cancer treatment approaches based on preclinical and clinical evidence from inhibitors such as MLN4924 and TAS4464.
Authors
- Qiu Peng (ORCID: https://orcid.org/0000-0001-7085-080X)
- Zhengdong Deng (ORCID: https://orcid.org/0000-0001-8009-1683)
- Jianming Wang (ORCID: https://orcid.org/0000-0003-2685-4437)
- Wei Yao (ORCID: https://orcid.org/0000-0002-4054-5916)
- Ming Zhang (ORCID: https://orcid.org/0000-0003-2956-4056)
- Yunxiang Feng
- Tao Yang (ORCID: https://orcid.org/0000-0003-3127-3944)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.jare.2025.11.010
- Citations
- 1
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.05