Central Retinal Sensitivity Decline in RPGR-Related Retinal Phenotypes
This study reveals significantly different rates of functional decline between RPGR phenotypes, with CORD patients at markedly higher risk of early central vision loss. These findings support the use of microperimetry as a sensitive outcome measure and provide critical survival data for clinical trial design, patient counseling, and therapeutic prioritization. Patients with cone-dominated phenotypes may benefit from earlier intervention.
Authors
- Amandeep S. Josan (ORCID: https://orcid.org/0000-0003-1808-6546)
- Laura J. Taylor (ORCID: https://orcid.org/0000-0001-7072-0853)
- Robert E. MacLaren (ORCID: https://orcid.org/0000-0002-3096-4682)
- Jasmina Cehajic‐Kapetanovic (ORCID: https://orcid.org/0000-0002-9956-6412)
- Shabnam Raji (ORCID: https://orcid.org/0009-0003-6779-5194)
Institutions
- Oxford University Hospitals NHS Trust (GB)
Publication Details
- Journal
- American Journal of Ophthalmology
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1016/j.ajo.2025.11.002
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00