Activation of Endothelial TRPV4 Exacerbates Myocardial Ischemia-Reperfusion Injury via Vascular Integrity Impairment
Activation of endothelial TRPV4 CECs exacerbates post-IR vascular hyperpermeability and myocardial injury by impairing barrier integrity and promoting apoptosis. Targeting endothelial TRPV4 might represent a promising therapeutic strategy to mitigate myocardial IR injury.
Authors
- Hongyun Ruan
- Yimei Du
- Bing Han (ORCID: https://orcid.org/0000-0002-3523-0573)
- Yan Liu (ORCID: https://orcid.org/0000-0002-8581-2571)
- Miaomiao Zhang (ORCID: https://orcid.org/0000-0003-4657-5320)
- Zixuan Li (ORCID: https://orcid.org/0009-0000-9617-3982)
- Yingyu Chen (ORCID: https://orcid.org/0000-0002-1559-5698)
- Yan Zou (ORCID: https://orcid.org/0000-0001-9740-317X)
Institutions
- Xuzhou Medical College (CN)
- Wuhan Union Hospital (CN)
- Xuzhou Central Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Canadian Journal of Cardiology
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.cjca.2025.11.007
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00