Comparative Analysis of Kisspeptin Levels and KISS1 Gene Polymorphism in Patients with Polycystic Ovary Syndrome (PCOS): Correlation with the Luteinizing Hormone-Follicle-Stimulating Hormone Ratio and PCOS-Associated Variables

Kisspeptin and LH waist-hip ratio (WHR) levels were significantly higher in PCOS patients when compared to the healthy control group (p value < 0.0001). Kisspeptin level was positively correlated with serum LH level (r = 0.92) and LH/FSH ratio (r = 0.45). The frequency of the CC genotype was higher in the PCOS group (p-value < 0.05). One novel single-nucleotide polymorphism (SNP, rs3924587 C>T) was detected. Conclusion: Kisspeptin, LH, and the LH:FSH ratio were higher in patients with PCOS compared to healthy controls. KISS1 polymorphism was found to have a significant impact on various metabolic and endocrine parameters.