Behavioral impact of chemogenetic manipulations of 5-HT DRN neurons in transgenic Tph2-iCre rats
This study confirms some of the findings of prior chemo- and optogenetic studies in mice showing a role of 5-HT DRN neurons in anxiety-like behaviors but did not support effects in the FST model or in reinstatement of morphine CPP. Given the growing availability of transgenic rat lines, future studies in transgenic rats are needed to help dissect a complex literature on the behavioral functions of the 5-HT system.
Authors
- Lynn G. Kirby (ORCID: https://orcid.org/0000-0001-5684-6716)
- Nicholas McCloskey
- Chen Li (ORCID: https://orcid.org/0009-0001-0671-3904)
Institutions
- Temple University (US)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1007/s00213-025-06947-z
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00