Generation of implant-type tissue-engineered cartilage from human embryonic stem cell-derived chondrocytes
We successfully established a reproducible method for isolating and expanding chondrocytes from hESC-derived cartilage tissue. Under optimized culture conditions, these cells demonstrated the capacity for redifferentiation and <i>in vivo</i> cartilage regeneration, highlighting their potential as a stable and scalable allogeneic cell source for cartilage repair.
Authors
- Yukiyo Asawa
- Akihiro Umezawa (ORCID: https://orcid.org/0000-0002-0485-6653)
- Makoto Komura (ORCID: https://orcid.org/0000-0002-8905-8019)
- Shin Enosawa (ORCID: https://orcid.org/0000-0002-0818-8998)
- Junlong Chen
- Tomoyuki Kawasaki
- Yen‐Chih Huang (ORCID: https://orcid.org/0000-0002-2816-3202)
- Yasushi Fuchimoto (ORCID: https://orcid.org/0000-0003-3580-3359)
- Hidenori Akutsu
- Kazuto Hoshi
- Arhans Chairul Ismael
Institutions
- University of Tokyo Hospital (JP)
- National Center For Child Health and Development (JP)
- The University of Tokyo (JP)
- International University of Health and Welfare (JP)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1016/j.reth.2025.10.012
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00