Pharmacodynamic effects and plasma pharmacokinetics of N, N-dimethyltryptamine after intranasal versus subcutaneous administration in male rats
Our findings show the feasibility of using IN administration to deliver DMT in a reproducible and non-invasive manner. Importantly, the maximal DMT concentrations in rats given low IN doses (i.e., 30.2-55.6 ng/mL DMT) overlap with those reported in humans receiving psychoactive doses.
Authors
- Michael H. Baumann (ORCID: https://orcid.org/0000-0001-7758-1470)
- Christopher G. Witowski (ORCID: https://orcid.org/0000-0003-2592-0017)
- Grant C. Glatfelter (ORCID: https://orcid.org/0000-0003-1011-9083)
- Jacqueline L. von Salm (ORCID: https://orcid.org/0000-0003-2277-5491)
- Alex J. Krotulski (ORCID: https://orcid.org/0000-0003-1775-1882)
- Sara E. Walton (ORCID: https://orcid.org/0009-0003-4461-5293)
Institutions
- National Institute on Drug Abuse (US)
- Fredric Rieders Family Foundation (US)
- Spectrum Research (United States) (US)
- Temple University (US)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1007/s00213-025-06879-8
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Institute on Drug Abuse