Comprehensive and quantitative urinary metabolomic profiling for improved characterization of diabetic nephropathy
Quantitative urinary metabolomics revealed metabolic perturbations reflective of DN pathophysiology and identified candidate metabolite panels with potential for non-invasive disease characterization. These findings, though preliminary, provide a foundation for validation in larger, longitudinal cohorts and for integrating urinary metabolomics into precision diagnostics for diabetic kidney disease.
Authors
- David S. Wishart (ORCID: https://orcid.org/0000-0002-3207-2434)
- Yamilé López‐Hernández (ORCID: https://orcid.org/0000-0002-1068-603X)
- José de la Cruz Moreira Hernández
- Juan José Oropeza-Valdez (ORCID: https://orcid.org/0000-0003-1093-9970)
- Elena Jaime-Sánchez (ORCID: https://orcid.org/0000-0003-2090-5280)
- Juan Ernesto López-Ramos (ORCID: https://orcid.org/0000-0002-5598-628X)
- Valeria Maeda-Gutiérrez (ORCID: https://orcid.org/0000-0002-0852-8315)
- María Fernanda Romo-García
- Jose Antonio Moreno (ORCID: https://orcid.org/0000-0002-0055-8288)
- Jiamin Zheng (ORCID: https://orcid.org/0000-0002-6120-7035)
- Rupasri Mandal
Institutions
- University of Alberta (CA)
- Autonomous University of Queretaro (MX)
- Universidad Politécnica de Zacatecas (MX)
- Hospital General De Zona (MX)
- Universidad Autónoma de Zacatecas "Francisco García Salinas" (MX)
- Instituto Politécnico Nacional (MX)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Metabolomics
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1007/s11306-025-02371-8
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81