ECoGNet: an EEG-based Effective Connectivity Graph Neural Network for Brain Disorder Detection

Alzheimer’s Disease (AD) and Frontotemporal Dementia (FTD), among the most prevalent neurodegenerative disorders, disrupt brain activity and connectivity, highlighting the need for tools that can effectively capture these alterations. Effective Connectivity Networks (ECNs), which model causal interactions between brain regions, offer a promising approach to characterizing AD and FTD related neural changes. In this study, we estimate ECNs from EEG traces using a state-of-the-art causal discovery method specifically designed for time-series data, to recover the causal structure of the interactions between brain areas. The recovered ECNs are integrated into a novel Graph Neural Network architecture (ECoGNet), where nodes represent brain regions and edge features encode causal relationships. Our method combines ECNs with features summarizing local brain dynamics to improve AD and FTD detection. Evaluated on a publicly available EEG dataset, the proposed approach demonstrates superior performance compared to models that either use non-causal connectivity networks or omit connectivity information entirely.