Secondary Hypertrophic Osteoarthropathy (HOA) or Pierre Marie-Bamberger Syndrome Revealing Lung Adenocarcinoma

Digital clubbing, excruciating polyarthritis, and periosteal thickening of long bones are all features of the uncommon clinical syndrome known as hypertrophic osteoarthropathy (HOA). The most frequent association is lung cancer, which often presents as a paraneoplastic syndrome. We report the case of a 54-year-old male smoker who presented with joint pain and digital clubbing. Further investigations revealed a stage IV primary lung adenocarcinoma. Bone scintigraphy, performed after the diagnosis of the primary tumor, demonstrated increased uptake in the cortical bone of the lower limbs, with higher activity in both the axial and peripheral skeleton. The diagnosis of secondary HOA was established. The patient received palliative chemotherapy, which resulted in partial improvement of the articular symptoms. This case highlights the importance of considering HOA as a possible paraneoplastic manifestation, particularly in patients with lung cancer.