Concomitant changes in regional myocardial deformation and intraventricular pressure gradients in normal and sedated goats: advanced multimodal echocardiographic study
This study utilizes two novel imaging techniques to assess changes observed in cardiac function in goats after sedation. Xylazine, an α2-agonist, induces loading alterations that disproportionately affect wall mechanics, reducing circumferential and radial shortening as well as IVPG parameters. Our findings confirm that CMME and 2D-STE are sensitive tools to detect subtle, region-specific alterations in the IVPG and myocardial function, respectively, in ruminants, complementing conventional echocardiographic indices. This may have important implications for both clinical monitoring and experimental designs where α₂-adrenergic agonists are employed.
Authors
- Gen Watanabe (ORCID: https://orcid.org/0000-0001-7611-4678)
- Ryou Tanaka (ORCID: https://orcid.org/0000-0001-9948-6490)
- Haney Samir (ORCID: https://orcid.org/0000-0002-7227-1067)
- Ahmed S. Mandour (ORCID: https://orcid.org/0000-0001-6256-4539)
- Katsuhiro Matsuura (ORCID: https://orcid.org/0000-0002-6047-2865)
- Ahmed Farag (ORCID: https://orcid.org/0000-0002-1953-4294)
- Tomohiko Yoshida (ORCID: https://orcid.org/0000-0003-4311-9311)
- Lina Hamabe (ORCID: https://orcid.org/0000-0002-5291-925X)
Institutions
- Suez Canal University (EG)
- Cairo University (EG)
- Zagazig University (EG)
- University of Florida (US)
- Veterinary Medical Center (JP)
- Obihiro University of Agriculture and Veterinary Medicine (JP)
- Tokyo University of Agriculture and Technology (JP)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1186/s12917-025-05087-y
- Primary Topic
- Cardiovascular Conditions and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00