Dysfunctional Alternative Polyadenylation Modifies the Penetrance of <scp> <i>LRRK2</i> </scp> Variants in Parkinson's Disease
Dysfunctional APA is a potential modifier of LRRK2 variant penetrance, contributing to PD onset. © 2025 International Parkinson and Movement Disorder Society.
Authors
- Pei Yu (ORCID: https://orcid.org/0000-0001-7992-0480)
- Kun Xia (ORCID: https://orcid.org/0000-0001-8090-6002)
- Yuanfeng Huang (ORCID: https://orcid.org/0009-0005-0423-8491)
- Jifeng Guo (ORCID: https://orcid.org/0000-0002-3658-3928)
- Yu Zhang (ORCID: https://orcid.org/0000-0003-4952-8095)
- Jinchen Li (ORCID: https://orcid.org/0000-0001-5522-806X)
- Yixiao Zhu
- Beisha Tang (ORCID: https://orcid.org/0000-0003-2120-1576)
- Bin Li (ORCID: https://orcid.org/0000-0002-8979-610X)
- Zheng Wang (ORCID: https://orcid.org/0000-0001-7138-8581)
- Guihu Zhao (ORCID: https://orcid.org/0000-0003-4033-1843)
- Yijing Wang (ORCID: https://orcid.org/0000-0002-5267-5697)
- Songyu Yang
- Qiao Zhou (ORCID: https://orcid.org/0000-0001-5929-5438)
Institutions
- Central South University (CN)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
- University of South China (CN)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1002/mds.70119
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Central South University
- Hunan Provincial Innovation Foundation for Postgraduate
- Fundamental Research Funds for the Central Universities