Genomic insights into ST85 and ST158 belonging to recently emerged global clones of multidrug-resistant Acinetobacter baumannii isolates from Egypt: in vitro assessment of repurposed drug–antibiotic combinations
The current study provides an in-depth characterization of the collected MDRAB isolates from the global clones GC9 and GC10. The endemicity of these clones necessitates strategies to mitigate ongoing MDRAB outbreaks in countries like Egypt. Combination of NAC with meropenem or levofloxacin represents a promising treatment option against the newly emerged global clones that needs further in vivo testing.
Authors
- Mona S. El Far
- David Baker (ORCID: https://orcid.org/0000-0003-2126-7436)
- Benjamin A. Evans (ORCID: https://orcid.org/0000-0001-6849-9758)
- Azza S. Zakaria (ORCID: https://orcid.org/0000-0003-3772-1381)
- Mervat A. Kassem (ORCID: https://orcid.org/0000-0002-5815-6898)
- Eva A. Edward (ORCID: https://orcid.org/0000-0001-9426-5074)
Institutions
- University of East Anglia (GB)
- Quadram Institute (GB)
- Alexandria University (EG)
Publication Details
- Journal
- Annals of Clinical Microbiology and Antimicrobials
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1186/s12941-025-00829-0
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Development Fund