An Uncommon Case of Cerebellar Leukoencephalopathy Secondary to Low-Dose Methotrexate

Methotrexate (MTX) is a commonly used disease-modifying antirheumatic drug in the treatment of rheumatoid arthritis (RA). MTX neurotoxicity in an RA population is uncommon, with few case reports describing this phenomenon.<sup>1-3</sup>

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Publication Details

Journal
The Journal of Rheumatology
Published
2025-11-15
DOI
https://doi.org/10.3899/jrheum.2025-0776
Primary Topic
Neurological Complications and Syndromes
Type
article
Field-Weighted Citation Impact
0.00
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article

An Uncommon Case of Cerebellar Leukoencephalopathy Secondary to Low-Dose Methotrexate

Tai‐Juan Aw, Sharmayne R.E. Brady, Dana Yen Lin Lee
The Journal of Rheumatology
Neurological Complications and Syndromes
article

An Uncommon Case of Cerebellar Leukoencephalopathy Secondary to Low-Dose Methotrexate

Tai‐Juan Aw, Sharmayne R.E. Brady, Dana Yen Lin Lee
article en

Abstract

Methotrexate (MTX) is a commonly used disease-modifying antirheumatic drug in the treatment of rheumatoid arthritis (RA). MTX neurotoxicity in an RA population is uncommon, with few case reports describing this phenomenon.<sup>1-3</sup>

The Journal of Rheumatology
Arthritis Australia (AU), Peninsula Health (AU), Alfred Health (AU), Monash University (AU)
Openalex Percentile: Top 59%
Neurological Complications and Syndromes
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