Recent Synthetic Transformation of 1,1‐Dibromoalk‐1‐enes

ABSTRACT 1,1‐Dibromoalk‐1‐enes are a pivotal class of organic synthons and occupy an outstandingly important role in both academic and industrial communities due to their accessibility and commercial availability. The development of novel, powerful, and highly efficient strategy that employed those cost‐effective reagents for the selective assembly of a great deal of structurally diverse elaborated molecular architectures has attracted considerable interest in organic synthesis, medicinal chemistry, and materials science. Over the past few decades, a resurgence of interest regarding 1,1‐dibromoalk‐1‐enes has been witnessed, and substantial research efforts have been dedicated to investigating their reactivity and synthetic applications, with primary focus on developing efficient methodologies for constructing structurally diverse heterocyclic frameworks. In this regard, numerous reaction strategies featuring high reactivity, operational simplicity, and excellent atom economy have been systematically explored, thereby expanding the synthetic utility of 1,1‐dibromoalk‐1‐enes in modern organic chemistry. This review summarizes the development of 1,1‐dibromoalk‐1‐enes through different types of reactions, which could be classified into the following categories: (1) 1,1‐dibromoalk‐1‐ene as alkenylation reagent; (2) 1,1‐dibromoalk‐1‐ene as alkynylation reagent; (3) cyclization reaction of 1,1‐dibromoalk‐1‐enes; and (4) other types of reactions of 1,1‐dibromoalk‐1‐ene.