Sex Differences in Leptin Levels in Children and Adolescents with Normal Weight and Overweight/Obesity Across Pubertal Stages: A Systematic Review and Meta-analysis
The sex-specific differences in leptin levels, characteristic of normal-weight (pre-)pubertal children is lost in obesity. Therefore, leptin levels alone are unlikely to explain why obesity accelerates puberty in girls more than in boys. A combined effect with other factors, such as sex dimorphism in kisspeptin, may play a role.
Authors
- Erica L T van den Akker (ORCID: https://orcid.org/0000-0001-5352-9328)
- Jenny A. Visser (ORCID: https://orcid.org/0000-0001-7182-3571)
- Eline E. P. L. van der Walle (ORCID: https://orcid.org/0000-0001-7789-7627)
- Alejandra Virginia Rodriguez Rondon (ORCID: https://orcid.org/0009-0006-8398-4667)
- Rutuja Dhamale
Institutions
- Erasmus MC (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1210/clinem/dgaf621
- Citations
- 2
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 1.83