Monoammonium glycyrrhizinate ameliorates mitochondrial dysfunction-mediated oxidative stress and neuroinflammation via the NRF2/NQO1 axis after spinal cord injury
This study identifies MAG as a novel activator of the KEAP1/NRF2/NQO1 axis, alleviating microglial mitochondrial dysfunction and neuroinflammation post-SCI. These findings provide mechanistic insights into MAG's neuroprotective actions and support its therapeutic potential.
Authors
- Tianyi Wang (ORCID: https://orcid.org/0009-0001-6509-5536)
- Qianqiu Li (ORCID: https://orcid.org/0009-0009-1231-2179)
- Mingjie Xia (ORCID: https://orcid.org/0009-0000-1566-3024)
- Zheng Zhou (ORCID: https://orcid.org/0000-0003-3433-751X)
- Jianzhong Zhou (ORCID: https://orcid.org/0000-0002-5898-6875)
- Zhiming Cui (ORCID: https://orcid.org/0000-0001-9197-5548)
- Zhanyang Qian (ORCID: https://orcid.org/0000-0002-6431-9008)
- Jian Huang (ORCID: https://orcid.org/0009-0001-4188-4602)
- Guanhua Xu (ORCID: https://orcid.org/0009-0002-8272-1743)
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Second People's Hospital of NanTong (CN)
Publication Details
- Journal
- Redox Report
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1080/13510002.2025.2585221
- Citations
- 3
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 4.67