Mn- and DMAP-Promoted Formal [3 + 2]-Cycloaddition of Cyanoacetates and Malonates with Vinyl Azides for the Synthesis of α-Quaternary Ene-γ-Lactams
A Mn- and DMAP-promoted [3 + 2]-cycloaddition of cyanoacetates and malonates with vinyl azides was presented, enabling the concise synthesis of α-quaternary ene-γ-lactam. The utility of the catalytic system was demonstrated by the concise synthesis of the natural product sargassumlactam.
Authors
- Bi‐Qin Wang
- Wenhao Yu (ORCID: https://orcid.org/0000-0003-2991-5362)
- Jian Xiao (ORCID: https://orcid.org/0000-0001-9261-5237)
- Xuanfeng Li
- Bin Chen (ORCID: https://orcid.org/0000-0002-9907-7002)
- Peng Cao (ORCID: https://orcid.org/0000-0001-8199-0015)
- Rui He (ORCID: https://orcid.org/0000-0002-9263-5913)
- Minghui Xu (ORCID: https://orcid.org/0000-0003-3444-8332)
- Min Yang (ORCID: https://orcid.org/0000-0001-8338-9725)
- Hai‐Liang Ni (ORCID: https://orcid.org/0009-0000-1667-6214)
Institutions
- Sichuan University (CN)
- Ingenierie des Materiaux polymeres (FR)
- Sichuan Normal University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1021/acs.joc.5c01980
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00