Association of Type III and Type VI Collagen Neoepitopes With Disease Severity in Systemic Sclerosis
PRO-C3 and PRO-C6 correlated with skin disease severity, whereas C3M and C6M correlated with lung disease severity. Collagen turnover biomarkers correlated with CRP, IL-6, and IFN-inducible proteins, providing support for the link between inflammation and fibrosis in SSc.
Authors
- Ami A. Shah (ORCID: https://orcid.org/0000-0002-1139-2009)
- Laura K. Hummers (ORCID: https://orcid.org/0000-0002-4864-4011)
- Leland W.K. Chung (ORCID: https://orcid.org/0000-0003-0072-6939)
- Duncan F. Moore (ORCID: https://orcid.org/0000-0001-9469-0919)
- Kimberly S. Lakin (ORCID: https://orcid.org/0000-0001-9343-5545)
- Yiming Luo (ORCID: https://orcid.org/0000-0001-7710-2425)
- Nora Sandorfi (ORCID: https://orcid.org/0009-0009-5877-3552)
- Elizabeth R. Volkmann (ORCID: https://orcid.org/0000-0003-3750-6569)
- Shervin Assassi (ORCID: https://orcid.org/0000-0002-8059-9978)
- Carrie Richardson (ORCID: https://orcid.org/0000-0002-2541-175X)
- Maureen D. Mayes (ORCID: https://orcid.org/0000-0001-5070-2535)
- Zsuzsanna H. McMahan (ORCID: https://orcid.org/0000-0001-6461-8940)
- Dorota Lebiedz‐Odrobina
- Elana J. Bernstein (ORCID: https://orcid.org/0000-0001-5560-6390)
- Virginia Steen (ORCID: https://orcid.org/0000-0002-6333-0133)
- Tracy Frech (ORCID: https://orcid.org/0000-0002-5472-3840)
- Ali Yağiz Ayla (ORCID: https://orcid.org/0000-0003-2581-7992)
- Carleigh Zahn (ORCID: https://orcid.org/0009-0005-9683-6973)
- Ankoor R. Shah (ORCID: https://orcid.org/0000-0002-6315-8089)
- Luke Evnin
- Brian Skaug (ORCID: https://orcid.org/0000-0002-6689-4655)
- Jessica Gordon (ORCID: https://orcid.org/0000-0001-8068-0592)
- Flavia V. Castelino
- John M. VanBuren (ORCID: https://orcid.org/0000-0003-1350-5764)
- Ashima Makol (ORCID: https://orcid.org/0000-0002-8748-898X)
- Victoria K. Shanmugam (ORCID: https://orcid.org/0000-0002-5882-4884)
- Meng Zhang (ORCID: https://orcid.org/0000-0003-4935-4005)
- Jerry A. Molitor
- Dinesh Khanna
- Wenjin Zheng
- Faye N. Hant
Institutions
- Northwestern University (US)
- Hospital for Special Surgery (US)
- University of Minnesota (US)
- Mayo Clinic (US)
- Johns Hopkins University (US)
- Medical University of South Carolina (US)
- University of California, Los Angeles (US)
- Duke University (US)
- Palo Alto University (US)
- Georgetown University (US)
- George Washington University (US)
- VA Palo Alto Health Care System (US)
- University of Utah (US)
- University of Michigan (US)
- Johns Hopkins Medicine (US)
- Georgetown University Medical Center (US)
- Massachusetts General Hospital (US)
- Northwestern University (PH)
- VA Tennessee Valley Healthcare System (US)
- Michigan Medicine (US)
- Mayo Clinic in Arizona (US)
- Scleroderma Foundation (US)
- Northwestern Medicine (US)
- The University of Texas Health Science Center (US)
- Columbia University (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- The Journal of Rheumatology
- Published
- 2025-11-15
- DOI
- https://doi.org/10.3899/jrheum.2025-0532
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00