Impact of All-trans Retinoic Acid on Skeletal Development: Mechanisms of Growth Plate Closure
ATRA accelerates growth plate closure through the ITGB2-YAP axis, disrupting Wnt/β-catenin signaling. These findings establish a mechanistic framework for developing therapeutic strategies targeting ITGB2 or YAP to delay premature growth plate senescence in pediatric disorders.
Authors
- Yanan Zhang (ORCID: https://orcid.org/0000-0002-7714-0103)
- Xiaoli Wu (ORCID: https://orcid.org/0000-0001-5587-2146)
- Xuan Fan
- Yalei Pi (ORCID: https://orcid.org/0000-0001-5401-6372)
- Zhixing Mei (ORCID: https://orcid.org/0000-0001-9650-1536)
- Huifeng Zhang (ORCID: https://orcid.org/0000-0003-1154-3986)
- Yutong Xing
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2025-11-14
- DOI
- https://doi.org/10.2174/0113862073424590251103061707
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00