The Role of the Pulmonary Microenvironment in Driving Transition From Systemic Sclerosis to Systemic Sclerosis–Associated Interstitial Lung Disease
Due to the limited number of studies, we were unable to perform a metaanalysis on mediators between SSc and SSc-ILD, highlighting the need for further studies. However, our review strongly highlights the involvement of the pulmonary epithelium in SSc-ILD, contributing to positive feedback between injured epithelial cells and fibroblast activation/fibrosis. Further research into the role of the epithelium is needed to identify novel mechanisms leading to SSc-ILD that could serve as novel pharmacological targets.
Authors
- Guillermo López–Campos (ORCID: https://orcid.org/0000-0003-3011-0940)
- Steven O’Reilly (ORCID: https://orcid.org/0000-0001-7483-740X)
- Koray N Potel
- Nazia Chaudhuri (ORCID: https://orcid.org/0000-0003-3325-6996)
- Bettina Schock (ORCID: https://orcid.org/0000-0002-1433-0188)
- Julia Malitska
- Susan Sultani
- Rosa I Rodríguez Viera
Institutions
- Universidad de Las Palmas de Gran Canaria (ES)
- Queen's University Belfast (GB)
- University of Ulster (GB)
- Al-Farabi Kazakh National University (KZ)
- Durham University (GB)
- Altnagelvin Area Hospital (GB)
Publication Details
- Journal
- The Journal of Rheumatology
- Published
- 2025-11-15
- DOI
- https://doi.org/10.3899/jrheum.2025-0322
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Northern Ireland Chest Heart and Stroke