Assessment of pharmacognostical, physiochemical, and in-vitro anti-inflammatory potential of S. cordata

Background: The current study aimed to investigate the pharmacognostical, physiochemical, and anti-inflammatory potential of Sida cordata. In this study, macroscopic, microscopic, and physicochemical analyses were performed. Methodology: This medicinal plant, commonly used in traditional medicine, was evaluated using the in vitro albumin denaturation method. The study aimed to assess the plant's ability to inhibit protein denaturation, a critical factor in the inflammatory process. The water extract and acetic acid extract of Sida cordata were tested at various concentrations (10, 50, 100, 150, 200, 250 µg/ml), and the results indicated a dose-dependent inhibition of albumin denaturation. Result & Discussion: The rate of inhibition of egg albumin denaturation for water extract (WE) is 86.55±0.63, and acetic acid extract (AAE) is 82.18±1.43. The maximum inhibition observed was compared with the standard anti-inflammatory drug (diclofenac sodium). Conclusion: These findings suggest that the water and acetic acid extracts of Sida cordata possess significant anti-inflammatory activity, supporting its traditional use as a remedy for inflammatory conditions.