Molecular Pathways Involved in Drug-Induced Hepatotoxicity: A Mini Review

Drug-induced hepatotoxicity (DIH) poses a significant clinical challenge due to its unpredicta-ble nature and diverse manifestations. The liver, with its central role in metabolism and close association with the gastrointestinal tract, is particularly susceptible to drug-induced toxicity. DIH encompasses a spectrum of liver injuries, including hepatocellular, cholestatic, and mixed patterns, which may increase the risk of other liver diseases. This review examines diverse examples and molecular mechanisms under-lying DIH, highlighting the influence of genetic predisposition, drug interactions, and pre-existing liver conditions. Given the complexity and variability of hepatotoxic responses to numerous medications, un-derstanding these mechanisms is crucial for improving the diagnosis and management of DIH.