Maternal Diet‐Induced Excess Adiposity in Mice Disrupts Mid‐Gestation Decidual Immune and Vascular Homeostasis Without Impairing Spiral Artery Remodeling
These findings point towards decidual vascular inflammation and dysregulated angiogenesis during early placentation in pregnancies complicated by excess adiposity. This may stem from or induce shifts in resident immune cells, contributing to later placental dysfunction.
Authors
- Deborah M. Sloboda (ORCID: https://orcid.org/0000-0002-7410-4756)
- Tatiane Aparecida Ribeiro (ORCID: https://orcid.org/0000-0001-5687-1110)
- Katherine M. Kennedy (ORCID: https://orcid.org/0000-0003-1240-9703)
- Chethana Ellewela
- Dawn M. E. Bowdish (ORCID: https://orcid.org/0000-0001-6823-2957)
- Erica Yeo (ORCID: https://orcid.org/0000-0001-9167-4390)
- Christian J. Bellissimo (ORCID: https://orcid.org/0000-0001-5896-2622)
- Alexander G. Beristain (ORCID: https://orcid.org/0000-0002-1117-6242)
- Ariana E. Lewis (ORCID: https://orcid.org/0009-0008-6496-3355)
- Patrycja A. Jazwiec (ORCID: https://orcid.org/0000-0003-0517-4125)
- Ali A. Ashkar (ORCID: https://orcid.org/0000-0003-1139-1468)
- Jaskiran Bains
Institutions
- University of British Columbia (CA)
- McMaster University Medical Centre (CA)
- Institut de Recherche en Santé Digestive (FR)
- BC Children's Hospital (CA)
- McMaster University (CA)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1111/apha.70130
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.06
Funders
- McMaster University
- Canada Research Chairs
- Canadian Institutes of Health Research