Reverse Takotsubo Cardiomyopathy Caused by Repeated Guanfacine Overdose
An overdose of guanfacine, a medication used for treating attention-deficit hyperactivity disorder, can result in reverse takotsubo cardiomyopathy in a blood concentration-dependent manner. The cardiopulmonary time course of an extended-release guanfacine overdose spans approximately 2 weeks, with early critical respiratory failure, reverse takotsubo cardiomyopathy, and late QT prolongation.
Authors
- Kei Nishiyama (ORCID: https://orcid.org/0000-0003-3676-0135)
- Kazuki Deuchi
- Takeshi Kashimura (ORCID: https://orcid.org/0000-0002-9267-1017)
- Hajime Umezu
- Takayuki Kumaki
- Jun Egawa (ORCID: https://orcid.org/0000-0003-1346-4042)
- Takashi Kanbayashi (ORCID: https://orcid.org/0000-0001-9205-007X)
- Hiroki Tsuchiya (ORCID: https://orcid.org/0000-0002-9031-3638)
- Takayuki Inomata (ORCID: https://orcid.org/0000-0002-2199-6850)
- S. Hirayama
Institutions
- Niigata University Medical and Dental Hospital (JP)
- Niigata University (JP)
Publication Details
- Journal
- JACC Case Reports
- Published
- 2025-11-17
- DOI
- https://doi.org/10.1016/j.jaccas.2025.105915
- Citations
- 1
- Primary Topic
- Takotsubo Cardiomyopathy and Associated Phenomena
- Type
- article
- Field-Weighted Citation Impact
- 1.39