Comparison of breast and gastric HER2 immunohistochemistry (IHC) scoring criteria in the assessment of endometrial carcinoma
Breast and gastric scoring criteria show high concordance in endometrial carcinoma, with discordance primarily in equivocal tumors. RNA expression may help stratify equivocal from negative cases. Further study is needed to determine whether HER2 alterations at the DNA, RNA, or protein level predict response to newer generation HER2-targeted therapies.
Authors
- Cara Mathews (ORCID: https://orcid.org/0000-0001-8461-4568)
- Matthew J. Oliver (ORCID: https://orcid.org/0000-0003-3334-0581)
- Shuanzeng Wei (ORCID: https://orcid.org/0000-0002-0441-6973)
- Andrew Elliott (ORCID: https://orcid.org/0000-0002-4536-5244)
- Premal H. Thaker (ORCID: https://orcid.org/0000-0002-0568-6959)
- Jaclyn F. Hechtman (ORCID: https://orcid.org/0000-0003-2645-0985)
- Harris B. Krause (ORCID: https://orcid.org/0000-0003-3481-8364)
- Whitney R. Grither (ORCID: https://orcid.org/0000-0003-1053-6469)
- Matthew James Oberley (ORCID: https://orcid.org/0000-0001-6419-2513)
- Sharon Wu (ORCID: https://orcid.org/0000-0002-8336-6301)
- Rouba-Ali Fehmi (ORCID: https://orcid.org/0009-0003-0642-535X)
- Rachel L Furuya (ORCID: https://orcid.org/0000-0001-8259-2983)
- Matthew A. Powell (ORCID: https://orcid.org/0000-0002-1968-2772)
- Katherine E. Miller (ORCID: https://orcid.org/0000-0003-1054-0476)
- Mark G. Evans (ORCID: https://orcid.org/0000-0001-9358-9843)
- David A. Bryant
Institutions
- Fox Chase Cancer Center (US)
- Washington University in St. Louis (US)
- Brown University (US)
- University of Michigan (US)
- Temple University Health System (US)
- Caris Life Sciences (United States) (US)
Publication Details
- Journal
- Gynecologic Oncology
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1016/j.ygyno.2025.10.034
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00