Serum cFAS Content Correlates With Incidence of Peripheral Arterial Disease
There are currently no reliable serum biomarkers to aid in the diagnosis of peripheral artery disease (PAD). We hypothesized that circulating fatty acid synthase (cFAS) can be an independent diagnostic biomarker for PAD. Serum cFAS and demographics were compared for patients with and without PAD or chronic limb threatening ischemia (CLTI). Patients with PAD or CLTI had significantly higher serum cFAS content. We observed optimal cutoffs for cFAS in distinguishing between individuals with and without PAD or CLTI. Our study demonstrates that cFAS is an independent serum-based diagnostic biomarker for PAD, can distinguish between patients with PAD vs CLTI, and may predict disease severity.
Authors
- Batool Arif (ORCID: https://orcid.org/0009-0006-3610-0865)
- Mohamed S. Zaghloul (ORCID: https://orcid.org/0000-0002-1999-6528)
- Rodrigo Meade
- Amanda Penrose
- Clay F. Semenkovich (ORCID: https://orcid.org/0000-0003-1163-1871)
- Louai Alrata (ORCID: https://orcid.org/0000-0003-2730-1180)
- Mohamed A. Zayed (ORCID: https://orcid.org/0000-0001-9788-3417)
- Shahab Hafezi (ORCID: https://orcid.org/0000-0003-1832-8517)
- Khaled Shorbaji (ORCID: https://orcid.org/0000-0002-9371-9350)
- Larisa Belaygorod
- Wahid Abu‐Amer (ORCID: https://orcid.org/0000-0002-7455-6517)
- Stephen Gang Wu
- Sophia R. Pyeatte
Institutions
- Washington University in St. Louis (US)
Publication Details
- Journal
- JACC Basic to Translational Science
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1016/j.jacbts.2025.101411
- Primary Topic
- Peripheral Artery Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00